AQP8

Across TCGA patient cohorts, AQP8 mutation is significantly associated with the RNA expression of many other genes, with 1,764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AQP8-associated genes across cancer lineages are MIR2278, MIR3978, and MIR4681. Each is linked with AQP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP8-to-partner and partner-to-AQP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR2278 grouped by AQP8-low versus AQP8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP8→partner) and Y-score (partner→AQP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR2278 →	+1.155	+5.435	<.001	.005	3	2
COAD	MIR3978 →	+0.677	+6.251	.005	.001	3	2
COAD	MIR4681 →	+0.791	+5.693	<.001	.003	3	2
UCEC	NIPA1 →	+0.957	+3.700	<.001	.001	3	2
UCEC	SPATA5L1 →	+0.604	+3.491	<.001	.002	3	2
UCEC	SOAT1 →	+0.702	+3.329	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,764 associations by consensus.

MIR2278 by AQP8 expression — COAD

Explore this box plot interactively →