AQP8

Across TCGA pan-cancer cohorts, AQP8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AQP8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AQP8 RNA is repressed in tumor relative to normal tissue. In most cancer types AQP8 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where AQP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AQP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−8.077	<.001	12	view →
KIRC	Male	All	+0.111	<.001	11	view →
THCA	All	II,III,IV	+0.302	<.001	9	view →
READ	All	All	−8.006	<.001	7	view →
LIHC	Male	All	+1.136	<.001	7	view →
LUSC	All	II,III,IV	−0.250	<.001	7	view →
LUAD	All	II,III,IV	−0.122	.007	5	view →
KIRP	All	All	+0.149	.002	4	view →
PRAD	All	All	−0.212	.015	2	view →
STAD	Male	IV	−0.305	.009	1	view →
ESCA	Female	All	−0.226	.018	1	view →
BLCA	Male	IV	−0.170	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AQP8–COAD

Open the COAD breakdown →