AQP8

Across TCGA cell cohorts, AQP8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AQP8-associated genes across cancer lineages are MOS, OR1L3, and OR4E1. Each is linked with AQP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP8-to-partner and partner-to-AQP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MOS grouped by AQP8-low versus AQP8-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP8→partner) and Y-score (partner→AQP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MOS →	+0.018	+5.000	.004	.006	3	1
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	1
BREAST	OR4E1 →	+0.150	+5.781	<.001	.001	3	1
LARGE_INTESTINE	REG1B →	+2.538	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MOS by AQP8 expression — PANCREAS

Explore this box plot interactively →