AQP5

Across TCGA patient cohorts, AQP5 protein abundance is significantly associated with the RNA expression of many other genes, with 4,942 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible AQP5-associated genes across cancer lineages are AQP2, AQP6, and AGR2. Each is linked with AQP5 in more than 5 cancer types. Because this analysis shows association rather than direction, both AQP5-to-partner and partner-to-AQP5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AQP5 versus AQP2 in OV, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP5→partner) and Y-score (partner→AQP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AQP2 →	+1.042	+1.381	<.001	<.001	3	6
OV	AQP6 →	+1.179	+0.962	.001	<.001	3	6
UCEC	AGR2 →	+1.686	+1.270	.001	<.001	3	4
LUAD	MUC5B →	+2.665	+1.591	<.001	<.001	3	4
UCEC	SPDEF →	+1.812	+1.061	.003	.005	3	4
HNSC	KCTD14 →	+0.809	+0.822	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,942 associations by consensus.

AQP5 vs AQP2 — OV

Explore this scatter interactively →