AQP5

Across TCGA pan-cancer cohorts, AQP5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AQP5 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AQP5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AQP5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LGG are the cancer types where AQP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.852	0.649	<.001	104	view →
HNSC	OS	Quartile	All	0.866	0.710	<.001	95	view →
LGG	OS	Median	All	0.720	0.892	<.001	53	view →
THCA	DFS	Quartile	All	0.974	0.896	.006	34	view →
ESCA	DFS	Median	All	0.285	0.914	.002	33	view →
OV	OS	Quartile	All	0.935	0.790	<.001	30	view →
SCLC	OS	Median	All	0.800	0.603	.010	28	view →
SKCM	OS	Quartile	All	0.264	0.447	<.001	27	view →
COAD	DFS	Median	IV	0.340	0.607	.004	22	view →
GBM	DFS	Quartile	All	0.153	0.337	.008	18	view →
PAAD	OS	Quartile	All	0.187	0.564	.001	15	view →
LIHC	OS	Quartile	III,IV	0.336	0.528	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AQP5–UCEC (DFS)

Open the UCEC breakdown →