AQP5

Across TCGA pan-cancer cohorts, AQP5 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AQP5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AQP5 RNA is repressed in tumor relative to normal tissue. In most cancer types AQP5 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where AQP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AQP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−3.354	<.001	12	view →
KIRC	Female	III,IV	−1.704	<.001	12	view →
KIRP	Female	All	−1.589	<.001	11	view →
LUSC	All	III,IV	−2.964	<.001	9	view →
LUAD	All	II,III,IV	−1.418	.006	8	view →
KICH	Female	II,III,IV	−2.137	<.001	7	view →
UCEC	All	III,IV	+4.783	<.001	6	view →
BRCA	All	III,IV	−2.107	<.001	6	view →
THCA	All	All	+1.111	<.001	5	view →
PAAD	All	All	+4.272	.012	4	view →
COAD	All	All	+1.227	<.001	4	view →
CHOL	All	All	+2.186	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

AQP5–HNSC

Open the HNSC breakdown →