AQP5

Across TCGA cell cohorts, AQP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,965 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AQP5-associated GO terms across cancer lineages are Pancreatic juice secretion, Extracellular vesicle biogenesis, and T cell mediated cytotoxicity. Each is linked with AQP5 in more than 6 cancer types. Because this analysis shows association rather than direction, both AQP5-to-partner and partner-to-AQP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pancreatic juice secretion grouped by AQP5-low versus AQP5-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP5→partner) and Y-score (partner→AQP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Pancreatic juice secretion →	-0.188	-1.152	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Extracellular vesicle biogenesis →	+0.101	+0.619	.002	.002	3	5
LUNG_NSCLC_LUAD	T cell mediated cytotoxicity →	+0.177	+0.763	<.001	.004	3	5
LUNG_NSCLC_LUAD	Negative regulation of myeloid leukocyte mediated immunity →	+1.371	+0.773	<.001	.003	3	5
PANCREAS	Negative regulation of mast cell degranulation →	+1.284	+2.118	<.001	.007	3	5
STOMACH	Acetylcholine biosynthetic process →	+1.342	+2.885	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,965 associations by consensus.

Pancreatic juice secretion by AQP5 expression — BLOOD_Leukemia

Explore this box plot interactively →