AQP5

Across TCGA cell cohorts, AQP5 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AQP5-associated genes across cancer lineages are PTH, ENPP6, and OR6Q1. Each is linked with AQP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both AQP5-to-partner and partner-to-AQP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by AQP5-low versus AQP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP5→partner) and Y-score (partner→AQP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTH →	+0.056	+3.684	<.001	.006	3	1
LARGE_INTESTINE	ENPP6 →	+0.033	+3.793	.007	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PTH by AQP5 expression — LARGE_INTESTINE

Explore this box plot interactively →