AQP11

Across TCGA cell cohorts, AQP11 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,952 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AQP11-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Glycerolipid biosynthetic process, and Phospholipid biosynthetic process. Each is linked with AQP11 in more than 10 cancer types. Because this analysis shows association rather than direction, both AQP11-to-partner and partner-to-AQP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by AQP11-low versus AQP11-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AQP11→partner) and Y-score (partner→AQP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.166	+0.769	<.001	<.001	3	11
BONE	Glycerolipid biosynthetic process →	+0.039	+0.435	.004	.007	2	11
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.057	+0.896	<.001	.007	3	9
SOFT_TISSUE	Cytosolic transport →	+0.066	+0.522	<.001	.001	3	9
BONE	Protein localization to cytoplasmic stress granule →	+0.171	+0.565	<.001	.005	3	9
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.168	+0.470	.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,952 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by AQP11 expression — LUNG_SCLC

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