APOL4

Across TCGA patient cohorts, APOL4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,619 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOL4-associated proteins across cancer lineages are LCP2, GBP1, and GBP5. Each is linked with APOL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both APOL4-to-partner and partner-to-APOL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL4 versus LCP2 in HNSC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL4→partner) and Y-score (partner→APOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LCP2 →	+0.569	+1.432	<.001	<.001	3	7
HNSC	GBP1 →	+0.998	+1.182	<.001	<.001	3	6
HNSC	GBP5 →	+1.188	+1.340	<.001	<.001	3	6
HNSC	APOL2 →	+0.740	+1.295	<.001	<.001	3	6
PDAC	NECAP2 →	+0.225	+0.434	<.001	<.001	3	6
HNSC	ARHGAP25 →	+0.552	+1.116	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,619 associations by consensus.

APOL4 vs LCP2 — HNSC

Explore this scatter interactively →