APOL4

Across TCGA pan-cancer cohorts, APOL4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of APOL4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where APOL4 RNA is repressed in tumor relative to normal tissue. In most cancer types APOL4 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, STAD, and LUAD are the cancer types where APOL4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOL4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−1.682	<.001	10	view →
STAD	All	II,III,IV	+1.081	<.001	9	view →
LUAD	Female	II,III,IV	−1.250	<.001	8	view →
KIRP	Male	All	−1.357	<.001	7	view →
HNSC	All	II,III,IV	+0.979	<.001	7	view →
LUSC	Male	II,III,IV	−1.387	<.001	5	view →
UCEC	All	All	+1.496	.001	4	view →
BRCA	All	All	−0.336	.012	4	view →
COAD	All	II,III,IV	+0.464	.034	3	view →
CHOL	All	All	+1.193	.001	2	view →
KIRC	All	All	+0.364	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

APOL4–KICH

Open the KICH breakdown →