APOL4

Across TCGA pan-cancer cohorts, APOL4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated APOL4 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher APOL4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated APOL4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, BLCA, and KIRP are the cancer types where APOL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.397	0.268	<.001	123	view →
BLCA	OS	Median	All	0.517	0.336	<.001	112	view →
KIRP	DFS	Tertile	All	0.693	1.000	<.001	71	view →
OV	OS	Tertile	II,III,IV	0.423	0.305	.006	64	view →
UVM	OS	Median	All	0.430	0.740	.002	59	view →
LGG	DFS	Median	All	0.638	0.846	<.001	54	view →
UCS	DFS	Quartile	All	0.620	0.126	<.001	36	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	21	view →
COAD	DFS	Median	IV	0.378	0.586	.015	18	view →
ESCA	DFS	Quartile	III,IV	0.482	0.200	.020	15	view →
HNSC	DFS	Median	All	0.758	0.659	.007	12	view →
READ	DFS	Quartile	III,IV	0.538	0.919	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

APOL4–SKCM (OS)

Open the SKCM breakdown →