APOL4

Across TCGA patient cohorts, APOL4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,230 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOL4-associated genes across cancer lineages are DMXL2, SPG11, and OIP5. Each is linked with APOL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL4-to-partner and partner-to-APOL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOL4 versus DMXL2 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL4→partner) and Y-score (partner→APOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DMXL2 →	+0.616	+0.963	.006	.004	3	1
HNSC	SPG11 →	+0.569	+1.066	.006	.005	3	1
HNSC	OIP5 →	+0.573	+0.950	.006	.005	3	1
HNSC	RIPK2 →	+0.660	+1.179	<.001	.001	3	1
HNSC	IL7 →	+0.861	+1.046	.002	.001	3	1
HNSC	TFEC →	+1.275	+1.164	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,230 associations by consensus.

APOL4 vs DMXL2 — HNSC

Explore this scatter interactively →