APOL4

Across TCGA patient cohorts, APOL4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOL4-associated genes across cancer lineages are mTOR_pS2448, JNK_pT183_Y185, and Ku80. Each is linked with APOL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL4-to-partner and partner-to-APOL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by APOL4-low versus APOL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL4→partner) and Y-score (partner→APOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.173	-2.980	.016	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.223	-3.321	.006	.010	3	1
UCEC	Ku80 →	+0.278	+2.472	.014	.011	3	1
UCEC	MAPK_pT202_Y204 →	-0.459	-3.000	.043	.036	3	1
UCEC	Notch1 →	+0.272	+3.335	<.001	.005	3	1
UCEC	Akt_pS473 →	-0.767	-3.000	.026	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

mTOR_pS2448 by APOL4 expression — UCEC

Explore this box plot interactively →