APOL4

Across TCGA cell cohorts, APOL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,936 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOL4-associated GO terms across cancer lineages are CD8-positive, alpha-beta T cell differentiation, Regulation of protein localization to cell periphery, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with APOL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both APOL4-to-partner and partner-to-APOL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8-positive, alpha-beta T cell differentiation grouped by APOL4-low versus APOL4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL4→partner) and Y-score (partner→APOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CD8-positive, alpha-beta T cell differentiation →	+0.117	+0.466	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to cell periphery →	+0.070	+0.286	<.001	.009	3	6
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.062	+0.234	<.001	.003	3	6
CNS	Oxidative phosphorylation →	+0.052	+0.444	.004	.002	3	6
URINARY_TRACT	Cellular response to steroid hormone stimulus →	+0.063	+0.600	<.001	.002	3	5
URINARY_TRACT	Vesicle targeting, to, from or within Golgi →	+0.080	+0.662	.005	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,936 associations by consensus.

CD8-positive, alpha-beta T cell differentiation by APOL4 expression — BREAST

Explore this box plot interactively →