APOL4

Across TCGA cell cohorts, APOL4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOL4-associated genes across cancer lineages are OR10W1, SLC2A7, and AMELY. Each is linked with APOL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOL4-to-partner and partner-to-APOL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by APOL4-low versus APOL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL4→partner) and Y-score (partner→APOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	SLC2A7 →	+0.028	+4.196	<.001	.002	3	1
LARGE_INTESTINE	AMELY →	+0.036	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10W1 by APOL4 expression — LARGE_INTESTINE

Explore this box plot interactively →