APOL4

Across TCGA cell cohorts, APOL4 mutation is significantly associated with the mutation status of many other genes, with 1,119 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APOL4-associated genes across cancer lineages are ZNF384, NR4A2, and FEM1B. Each is linked with APOL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both APOL4-to-partner and partner-to-APOL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF384 grouped by APOL4-low versus APOL4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOL4→partner) and Y-score (partner→APOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF384 →	+4.000	+5.050	.008	.008	1	3
LARGE_INTESTINE	NR4A2 →	+2.422	+4.050	.004	.004	1	3
BLOOD_Leukemia	FEM1B →	+4.736	+5.560	.003	.003	1	3
LARGE_INTESTINE	DDX28 →	+3.744	+5.000	<.001	<.001	1	3
BLOOD_Leukemia	ELL2 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	ANO1 →	+4.736	+5.560	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,119 associations by consensus.

ZNF384 by APOL4 expression — BLOOD_Leukemia

Explore this box plot interactively →