APOE

Across TCGA patient cohorts, APOE mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOE-associated genes across cancer lineages are PRAMEF28P, RN7SL820P, and USP9YP10. Each is linked with APOE in more than 1 cancer types. Because this analysis shows association rather than direction, both APOE-to-partner and partner-to-APOE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF28P grouped by APOE-low versus APOE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOE→partner) and Y-score (partner→APOE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAMEF28P →	+0.147	+5.551	<.001	.004	3	1
UCEC	RN7SL820P →	+0.681	+4.982	<.001	.009	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
UCEC	SIGLEC24P →	+0.113	+5.420	<.001	.005	3	1
STAD	RNU6-861P →	+0.572	+5.187	<.001	.007	3	1
UCEC	OR4M1 →	+0.117	+5.242	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PRAMEF28P by APOE expression — UCEC

Explore this box plot interactively →