APOC3

Across TCGA patient cohorts, APOC3 RNA expression is significantly associated with the RNA expression of many other genes, with 9,218 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible APOC3-associated genes across cancer lineages are APOA1, F2, and APOA5. Each is linked with APOC3 in more than 23 cancer types. Because this analysis shows association rather than direction, both APOC3-to-partner and partner-to-APOC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOC3 versus APOA1 in CHOL, with a Pearson correlation of 0.95.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC3→partner) and Y-score (partner→APOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	APOA1 →	+6.312	+6.013	<.001	<.001	3	24
CHOL	F2 →	+4.102	+6.032	<.001	<.001	3	24
CHOL	APOA5 →	+3.780	+6.540	<.001	<.001	3	24
CHOL	KNG1 →	+4.145	+5.407	<.001	<.001	3	23
CHOL	AGXT →	+3.696	+5.863	<.001	<.001	3	23
CHOL	AHSG →	+5.077	+6.513	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,218 associations by consensus.

APOC3 vs APOA1 — CHOL

Explore this scatter interactively →