APOC3

Across TCGA pan-cancer cohorts, APOC3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated APOC3 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher APOC3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOC3 expression acts as an unfavorable survival marker, although some lineages such as LIHC and KIRP show a favorable association.

STAD, UVM, and ACC are the cancer types where APOC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.575	0.741	.001	96	view →
UVM	DFS	Tertile	All	0.264	0.824	<.001	90	view →
ACC	DFS	Tertile	III,IV	0.226	0.700	<.001	69	view →
HNSC	OS	Quartile	III,IV	0.638	0.753	.002	50	view →
LIHC	OS	Median	All	0.656	0.379	<.001	46	view →
CHOL	OS	Quartile	II,III,IV	0.087	1.000	.002	45	view →
MESO	OS	Quartile	All	0.311	0.616	<.001	41	view →
ESCA	OS	Quartile	All	0.601	1.000	.007	39	view →
OV	OS	Median	All	0.780	0.872	<.001	32	view →
KIRP	DFS	Median	IV	0.762	0.044	.021	24	view →
READ	DFS	Tertile	III,IV	0.832	0.254	.011	23	view →
UCS	DFS	Median	II,III,IV	0.628	0.270	.002	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

APOC3–STAD (DFS)

Open the STAD breakdown →