APOC1

Across TCGA patient cohorts, APOC1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,961 significant associations in total. GBM shows the largest number of these associations.

The most reproducible APOC1-associated genes across cancer lineages are IL6, SLC2A3, and SERPINE1. Each is linked with APOC1 in more than 8 cancer types. Because this analysis shows association rather than direction, both APOC1-to-partner and partner-to-APOC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOC1 versus IL6 in LSCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOC1→partner) and Y-score (partner→APOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL6 →	+1.525	+0.513	<.001	<.001	3	9
COAD	SLC2A3 →	+1.484	+1.146	<.001	<.001	3	9
HNSC	SERPINE1 →	+1.880	+0.458	<.001	.004	3	8
COAD	CD300E →	+1.362	+0.850	<.001	<.001	3	7
GBM	FCAR →	+0.900	+0.854	<.001	<.001	3	7
GBM	MMP19 →	+1.501	+0.925	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,961 associations by consensus.

APOC1 vs IL6 — LSCC

Explore this scatter interactively →