APOC1

Across TCGA pan-cancer cohorts, APOC1 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of APOC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOC1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where APOC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+5.337	<.001	12	view →
KIRP	Male	All	+5.524	<.001	11	view →
THCA	Male	All	+2.304	<.001	11	view →
STAD	Female	All	+4.068	<.001	10	view →
HNSC	Male	III,IV	+2.645	<.001	10	view →
BLCA	All	III,IV	+2.275	<.001	10	view →
KICH	Male	All	+2.491	<.001	9	view →
LUAD	Male	All	−1.776	<.001	9	view →
LUSC	Male	II,III,IV	−2.505	<.001	6	view →
BRCA	All	III,IV	+1.458	<.001	6	view →
CHOL	Female	All	−6.763	<.001	5	view →
COAD	All	II,III,IV	+0.985	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

APOC1–KIRC

Open the KIRC breakdown →