APOC1

Across TCGA pan-cancer cohorts, APOC1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated APOC1 data layer compared with 4 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher APOC1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated APOC1 expression acts as an unfavorable survival marker, although some lineages such as CESC and LIHC show a favorable association.

CESC, LIHC, and DLBC are the cancer types where APOC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.849	0.692	.004	58	view →
LIHC	OS	Median	All	0.836	0.715	<.001	51	view →
DLBC	DFS	Median	All	0.965	0.608	.002	39	view →
THCA	DFS	Tertile	IV	0.904	0.407	<.001	35	view →
ACC	DFS	Median	All	0.277	0.667	<.001	35	view →
LGG	OS	Quartile	All	0.381	0.620	<.001	28	view →
SKCM	OS	Tertile	All	0.936	0.820	.004	21	view →
ESCA	DFS	Quartile	All	0.391	0.594	.018	21	view →
THYM	DFS	Quartile	All	0.603	0.881	.005	20	view →
KIRP	OS	Quartile	All	1.000	0.854	.001	12	view →
KIRC	DFS	Median	All	0.744	0.843	.019	12	view →
COAD	DFS	Quartile	IV	0.322	0.710	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

APOC1–CESC (OS)

Open the CESC breakdown →