APOBEC3G

Across TCGA patient cohorts, APOBEC3G mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC3G-associated genes across cancer lineages are MEK1, PCNA, and P-Cadherin. Each is linked with APOBEC3G in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3G-to-partner and partner-to-APOBEC3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by APOBEC3G-low versus APOBEC3G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3G→partner) and Y-score (partner→APOBEC3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.410	+3.169	.041	.020	3	1
UCEC	PCNA →	+0.272	+3.169	.021	.020	3	1
UCEC	P-Cadherin →	-0.157	-3.156	.048	.020	2	1
UCEC	Tuberin →	+0.397	+3.169	.007	.020	1	1
UCEC	Caspase-8 →	-0.369	-3.169	.007	.020	1	1
UCEC	CD49b →	-0.453	-3.156	.003	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by APOBEC3G expression — UCEC

Explore this box plot interactively →