APOBEC3G

Across TCGA pan-cancer cohorts, APOBEC3G RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of APOBEC3G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOBEC3G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOBEC3G is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where APOBEC3G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC3G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.139	<.001	12	view →
KICH	Female	All	−1.170	<.001	7	view →
UCEC	All	II,III,IV	−1.960	<.001	6	view →
HNSC	All	All	+0.773	<.001	6	view →
KIRP	All	All	+0.624	.002	6	view →
STAD	All	II,III,IV	+0.882	.011	4	view →
CHOL	Female	All	+3.056	<.001	3	view →
LIHC	Female	II,III,IV	+0.826	.013	3	view →
PRAD	All	All	−1.390	<.001	2	view →
ESCA	All	All	+1.186	.010	2	view →
LUSC	Male	III,IV	−1.420	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

APOBEC3G–KIRC

Open the KIRC breakdown →