APOBEC3G

Across TCGA pan-cancer cohorts, APOBEC3G RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated APOBEC3G data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher APOBEC3G RNA is associated with better overall survival. In most high-consensus cancer types, elevated APOBEC3G expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, BLCA, and BRCA are the cancer types where APOBEC3G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.430	0.237	<.001	124	view →
BLCA	OS	Tertile	All	0.552	0.325	<.001	118	view →
BRCA	DFS	Median	All	0.928	0.873	<.001	72	view →
LGG	OS	Median	All	0.335	0.566	<.001	54	view →
CESC	OS	Median	All	0.929	0.809	<.001	44	view →
UVM	DFS	Tertile	II,III,IV	0.307	0.769	.001	34	view →
ESCA	DFS	Median	II,III,IV	0.476	0.241	.002	31	view →
SARC	OS	Median	All	0.884	0.789	.001	23	view →
UCEC	OS	Median	All	0.741	0.609	.009	22	view →
KIRC	DFS	Quartile	All	0.735	0.886	.003	19	view →
LUSC	OS	Quartile	III,IV	0.206	0.849	.009	15	view →
PAAD	OS	Quartile	All	0.235	0.510	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

APOBEC3G–SKCM (OS)

Open the SKCM breakdown →