APOBEC3G

Across TCGA cell cohorts, APOBEC3G mutation is significantly associated with the drug of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC3G-associated genes across cancer lineages are Lenalidomide, Dactinomycin, and CCT007093. Each is linked with APOBEC3G in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3G-to-partner and partner-to-APOBEC3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lenalidomide grouped by APOBEC3G-low versus APOBEC3G-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3G→partner) and Y-score (partner→APOBEC3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Lenalidomide →	+0.333	+2.684	.020	.035	3	1
LARGE_INTESTINE	Dactinomycin →	+0.488	+2.649	.038	.046	3	1
LARGE_INTESTINE	CCT007093 →	+0.320	+2.649	.031	.046	2	1
LARGE_INTESTINE	Epirubicin →	+0.670	+2.649	.015	.046	1	2
LARGE_INTESTINE	SGC-CBP30 →	+0.396	+2.649	.004	.046	2	1
LARGE_INTESTINE	I-BET-762 →	+0.502	+2.646	.040	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Lenalidomide by APOBEC3G expression — LARGE_INTESTINE

Explore this box plot interactively →