APOBEC3F

Across TCGA patient cohorts, APOBEC3F protein abundance is significantly associated with the RNA expression of many other genes, with 7,556 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible APOBEC3F-associated genes across cancer lineages are APOBEC3G, APOBEC3D, and APOBEC3C. Each is linked with APOBEC3F in more than 6 cancer types. Because this analysis shows association rather than direction, both APOBEC3F-to-partner and partner-to-APOBEC3F results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC3F versus APOBEC3G in HNSC, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3F→partner) and Y-score (partner→APOBEC3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	APOBEC3G →	+0.897	+0.398	.002	.001	3	7
GBM	APOBEC3D →	+0.369	+0.627	.003	.002	3	6
UCEC	APOBEC3C →	+1.171	+0.510	<.001	<.001	3	5
LSCC	IGHV3OR16-6 →	+0.967	+0.298	.001	.003	3	4
BRCA	KLRB1 →	+0.733	+0.390	<.001	.004	3	4
LUAD	CD72 →	+0.627	+0.294	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,556 associations by consensus.

APOBEC3F vs APOBEC3G — HNSC

Explore this scatter interactively →