APOBEC3F

Across TCGA pan-cancer cohorts, APOBEC3F RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of APOBEC3F’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOBEC3F RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOBEC3F is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where APOBEC3F tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC3F RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.108	<.001	11	view →
HNSC	Male	III,IV	+0.920	<.001	9	view →
KIRP	Male	All	+0.699	<.001	8	view →
KICH	Female	All	−1.020	<.001	7	view →
LUSC	Female	II,III,IV	+1.422	<.001	5	view →
STAD	All	II,III,IV	+0.720	.003	5	view →
ESCA	All	II,III,IV	+1.545	.003	4	view →
UCEC	All	All	−0.723	.010	4	view →
LIHC	All	All	+0.376	.012	4	view →
CHOL	Female	All	+2.300	<.001	3	view →
PRAD	All	All	−0.893	<.001	2	view →
LUAD	All	All	+0.382	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

APOBEC3F–KIRC

Open the KIRC breakdown →