APOBEC3F

Across TCGA pan-cancer cohorts, APOBEC3F RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated APOBEC3F data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher APOBEC3F RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated APOBEC3F expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

SKCM, UVM, and LGG are the cancer types where APOBEC3F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.690	0.544	<.001	138	view →
UVM	DFS	Tertile	All	0.332	0.821	.001	67	view →
LGG	OS	Median	All	0.308	0.574	<.001	54	view →
CESC	OS	Median	II,III,IV	0.848	0.635	.002	48	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.124	.001	48	view →
ACC	DFS	Tertile	All	0.216	0.629	.002	34	view →
BRCA	OS	Quartile	All	0.958	0.902	.002	34	view →
KIRC	DFS	Quartile	III,IV	0.836	0.513	.005	26	view →
LUSC	OS	Median	All	0.820	0.728	.004	23	view →
SCLC	DFS	Median	All	0.418	0.166	.004	20	view →
KICH	OS	Median	II,III,IV	0.800	0.975	.010	19	view →
CHOL	OS	Tertile	All	1.000	0.191	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

APOBEC3F–SKCM (DFS)

Open the SKCM breakdown →