APOBEC3F

Across TCGA patient cohorts, APOBEC3F mutation is significantly associated with the RNA expression of many other genes, with 3,089 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC3F-associated genes across cancer lineages are VDAC2, FAXDC2, and TOMM5. Each is linked with APOBEC3F in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3F-to-partner and partner-to-APOBEC3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VDAC2 grouped by APOBEC3F-low versus APOBEC3F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3F→partner) and Y-score (partner→APOBEC3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VDAC2 →	+0.432	+1.936	.007	.003	3	2
UCEC	FAXDC2 →	-0.670	-4.087	<.001	<.001	3	2
UCEC	TOMM5 →	+0.493	+2.828	.001	<.001	3	2
UCEC	GDE1 →	+0.474	+2.321	<.001	.001	3	2
UCEC	UFD1 →	+0.547	+3.513	<.001	<.001	3	2
UCEC	NIPAL2 →	-0.470	-1.925	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,089 associations by consensus.

VDAC2 by APOBEC3F expression — UCEC

Explore this box plot interactively →