APOBEC3F

Across TCGA cell cohorts, APOBEC3F RNA expression is significantly associated with the go_rna of many other GO terms, with 5,014 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible APOBEC3F-associated GO terms across cancer lineages are Regulation of viral process, Antigen processing and presentation of endogenous peptide antigen via MHC class I, and Antigen processing and presentation of peptide antigen via MHC class I. Each is linked with APOBEC3F in more than 12 cancer types. Because this analysis shows association rather than direction, both APOBEC3F-to-partner and partner-to-APOBEC3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of viral process grouped by APOBEC3F-low versus APOBEC3F-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3F→partner) and Y-score (partner→APOBEC3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.120	+1.243	<.001	<.001	3	13
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.299	+1.735	<.001	.001	3	12
SOFT_TISSUE	Antigen processing and presentation of peptide antigen via MHC class I →	+0.229	+1.713	<.001	.001	3	12
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen →	+0.297	+1.807	<.001	<.001	3	12
STOMACH	Autophagosome assembly →	+0.084	+1.400	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.144	+1.021	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,014 associations by consensus.

Regulation of viral process by APOBEC3F expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →