APOBEC3F

Across TCGA cell cohorts, APOBEC3F mutation is significantly associated with the RNA expression of many other genes, with 215 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC3F-associated genes across cancer lineages are CD300LB, CNGA2, and CBY1. Each is linked with APOBEC3F in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3F-to-partner and partner-to-APOBEC3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300LB grouped by APOBEC3F-low versus APOBEC3F-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3F→partner) and Y-score (partner→APOBEC3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CD300LB →	+0.006	+4.017	<.001	.007	3	1
OESOPHAGUS	CNGA2 →	+0.007	+4.392	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.543	+3.160	.008	.006	3	1
LARGE_INTESTINE	SAMM50 →	+0.503	+3.234	.007	.004	3	1
LARGE_INTESTINE	CCNJ →	+0.623	+3.212	.005	.006	3	1
LARGE_INTESTINE	CWH43 →	+0.661	+3.514	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 215 associations by consensus.

CD300LB by APOBEC3F expression — OESOPHAGUS

Explore this box plot interactively →