APOBEC3D

Across TCGA patient cohorts, APOBEC3D mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APOBEC3D-associated genes across cancer lineages are Caveolin-1, EGFR_pY1068, and eIF4E. Each is linked with APOBEC3D in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC3D-to-partner and partner-to-APOBEC3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by APOBEC3D-low versus APOBEC3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3D→partner) and Y-score (partner→APOBEC3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caveolin-1 →	-0.540	-2.321	.038	.033	3	2
UCEC	EGFR_pY1068 →	-0.241	-3.459	.007	.005	3	1
UCEC	eIF4E →	+0.160	+2.321	.035	.001	3	1
UCEC	eIF4G →	+0.255	+1.584	.022	.019	3	1
UCEC	A-Raf_pS299 →	-0.150	-2.906	<.001	.001	3	1
UCEC	FoxM1 →	+0.252	+1.925	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caveolin-1 by APOBEC3D expression — UCEC

Explore this box plot interactively →