APOBEC3D

Across TCGA pan-cancer cohorts, APOBEC3D RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of APOBEC3D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOBEC3D RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOBEC3D is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.

KIRC, KIRP, and UCEC are the cancer types where APOBEC3D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC3D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.663	<.001	12	view →
KIRP	All	All	+0.785	<.001	7	view →
UCEC	All	All	−1.123	<.001	6	view →
HNSC	All	All	+0.669	.001	6	view →
LUAD	All	All	+0.396	.002	5	view →
ESCA	All	II,III,IV	+1.634	.014	4	view →
STAD	All	II,III,IV	+0.952	.002	4	view →
LIHC	All	All	+0.465	.003	4	view →
CHOL	All	All	+1.843	<.001	3	view →
PRAD	All	All	−0.885	<.001	2	view →
THCA	All	All	−0.388	.020	2	view →
COAD	All	All	−0.329	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

APOBEC3D–KIRC

Open the KIRC breakdown →