APOBEC3D

Across TCGA pan-cancer cohorts, APOBEC3D RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated APOBEC3D data layer compared with 4 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher APOBEC3D RNA is associated with better overall survival. In most high-consensus cancer types, elevated APOBEC3D expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, UVM, and BLCA are the cancer types where APOBEC3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.412	0.253	<.001	135	view →
UVM	DFS	Median	All	0.410	0.795	<.001	114	view →
BLCA	OS	Median	All	0.682	0.535	<.001	91	view →
BRCA	OS	Tertile	All	0.603	0.500	<.001	85	view →
KIRC	OS	Quartile	All	0.536	0.727	<.001	83	view →
CESC	OS	Quartile	All	0.907	0.691	<.001	64	view →
LGG	DFS	Median	All	0.310	0.473	<.001	53	view →
ESCA	DFS	Median	II,III,IV	0.422	0.202	.001	45	view →
ACC	OS	Tertile	II,III,IV	0.767	0.277	.004	43	view →
HNSC	DFS	Quartile	III,IV	0.694	0.468	<.001	38	view →
UCEC	DFS	Quartile	All	0.695	0.342	.008	38	view →
SARC	OS	Tertile	All	0.849	0.649	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

APOBEC3D–SKCM (OS)

Open the SKCM breakdown →