APOBEC3C

Across TCGA cell cohorts, APOBEC3C protein abundance is significantly associated with the RNA expression of many other genes, with 983 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible APOBEC3C-associated genes across cancer lineages are LMNB1, SOX4, and PRR14L. Each is linked with APOBEC3C in more than 4 cancer types. Because this analysis shows association rather than direction, both APOBEC3C-to-partner and partner-to-APOBEC3C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APOBEC3C versus LMNB1 in LUNG_SCLC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC3C→partner) and Y-score (partner→APOBEC3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LMNB1 →	+0.795	+2.009	<.001	<.001	3	5
LUNG_SCLC	SOX4 →	+1.352	+1.238	.002	.006	3	4
LUNG_SCLC	PRR14L →	+1.119	+2.171	<.001	.004	3	4
OVARY	PSMA3 →	+0.805	+1.556	.003	.006	3	4
BLOOD_Leukemia	GIGYF1 →	+0.897	+0.759	.007	.001	3	4
SKIN	LTB4R2 →	+0.961	+1.258	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 983 associations by consensus.

APOBEC3C vs LMNB1 — LUNG_SCLC

Explore this scatter interactively →