APOBEC3C

Across TCGA pan-cancer cohorts, APOBEC3C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of APOBEC3C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where APOBEC3C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOBEC3C is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

KIRC, KIRP, and UCEC are the cancer types where APOBEC3C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC3C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.514	<.001	12	view →
KIRP	Female	All	+1.945	<.001	11	view →
UCEC	All	II,III,IV	−3.101	<.001	6	view →
BRCA	All	III,IV	−0.902	<.001	6	view →
HNSC	All	All	+0.644	<.001	6	view →
KICH	Female	All	−1.721	<.001	5	view →
LUSC	Female	II,III,IV	+1.368	<.001	5	view →
CHOL	Female	All	+4.283	<.001	3	view →
PRAD	All	All	−1.804	<.001	2	view →
LIHC	Female	II,III,IV	+1.135	.023	2	view →
ESCA	All	All	+0.936	.042	2	view →
COAD	All	All	−0.502	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

APOBEC3C–KIRC

Open the KIRC breakdown →