APOBEC1

Across TCGA cell cohorts, APOBEC1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOBEC1-associated genes across cancer lineages are MAGEB4, ACTRT1, and FTHL17. Each is linked with APOBEC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APOBEC1-to-partner and partner-to-APOBEC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by APOBEC1-low versus APOBEC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOBEC1→partner) and Y-score (partner→APOBEC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ACTRT1 →	+0.017	+4.273	<.001	.006	3	1
LARGE_INTESTINE	FTHL17 →	+0.060	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZAN →	+0.016	+4.467	<.001	.004	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.011	+4.684	<.001	.002	3	1
LARGE_INTESTINE	FBXO40 →	+0.006	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MAGEB4 by APOBEC1 expression — LARGE_INTESTINE

Explore this box plot interactively →