APOBEC1

Across TCGA pan-cancer cohorts, APOBEC1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of APOBEC1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where APOBEC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APOBEC1 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

LUAD, BRCA, and READ are the cancer types where APOBEC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOBEC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+1.547	<.001	7	view →
BRCA	Female	All	+0.062	.022	6	view →
READ	Female	All	+1.799	.005	4	view →
COAD	Male	All	+1.241	.005	3	view →
LUSC	Male	All	+0.163	.004	3	view →
KIRC	All	All	+0.018	.015	3	view →
PAAD	All	All	+2.885	.016	2	view →
PRAD	All	All	+0.025	.048	2	view →
THCA	All	All	−0.010	.015	2	view →
STAD	All	IV	−2.910	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

APOBEC1–LUAD

Open the LUAD breakdown →