APOB

Across TCGA cell cohorts, APOB RNA expression is significantly associated with the go_rna of many other GO terms, with 1,239 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible APOB-associated GO terms across cancer lineages are Negative regulation of cholesterol import, Neutrophil-mediated killing of fungus, and Regulation of microtubule nucleation. Each is linked with APOB in more than 11 cancer types. Because this analysis shows association rather than direction, both APOB-to-partner and partner-to-APOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cholesterol import grouped by APOB-low versus APOB-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOB→partner) and Y-score (partner→APOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of cholesterol import →	+2.183	+5.991	<.001	<.001	3	12
PANCREAS	Neutrophil-mediated killing of fungus →	-0.132	-0.013	<.001	.002	3	4
SKIN	Regulation of microtubule nucleation →	+0.080	+0.022	.003	.001	3	3
SKIN	Disruption of cellular anatomical structure in another organism →	-0.193	-0.030	.004	.008	3	3
BLOOD_Lymphoma	Response to kainic acid →	+0.110	+0.020	<.001	.002	3	3
SKIN	Regulation of leukocyte apoptotic process →	-0.053	-0.022	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,239 associations by consensus.

Negative regulation of cholesterol import by APOB expression — LIVER

Explore this box plot interactively →