APOB

Across TCGA pan-cancer cohorts, APOB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of APOB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where APOB RNA is repressed in tumor relative to normal tissue. In most cancer types APOB is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, KIRC, and BRCA are the cancer types where APOB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−0.642	.002	8	view →
KIRC	Male	III,IV	+1.887	<.001	7	view →
BRCA	All	III,IV	−1.485	<.001	6	view →
CHOL	All	All	−4.838	<.001	5	view →
UCEC	All	II,III,IV	−0.125	.006	4	view →
KICH	Male	II,III,IV	−0.246	<.001	3	view →
LUAD	All	III,IV	−0.073	.005	3	view →
PRAD	All	All	−0.203	<.001	2	view →
PAAD	Male	All	+0.120	.016	2	view →
COAD	All	III,IV	−0.246	.043	1	view →
KIRP	All	III,IV	−0.174	.017	1	view →
THCA	All	IV	−0.025	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

APOB–BLCA

Open the BLCA breakdown →