APOB

Across TCGA pan-cancer cohorts, APOB RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated APOB data layer compared with 13 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher APOB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOB expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCS show a favorable association.

LUAD, LGG, and KIRP are the cancer types where APOB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.346	0.608	<.001	120	view →
LGG	OS	Median	All	0.749	0.867	<.001	39	view →
KIRP	DFS	Median	II,III,IV	0.891	0.254	.002	34	view →
STAD	OS	Quartile	III,IV	0.194	0.614	.025	19	view →
UCS	DFS	Tertile	III,IV	0.535	0.156	.020	18	view →
LIHC	OS	Quartile	III,IV	0.732	0.225	.003	17	view →
COAD	OS	Median	III,IV	0.262	0.680	.002	16	view →
PCPG	DFS	Median	All	1.000	0.812	.003	15	view →
BLCA	OS	Tertile	III,IV	0.237	0.462	.007	13	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
SARC	OS	Quartile	All	0.904	0.820	.012	12	view →
SKCM	DFS	Median	IV	0.729	0.070	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

APOB–LUAD (DFS)

Open the LUAD breakdown →