APOB

Across TCGA cell cohorts, APOB mutation is significantly associated with the RNA expression of many other genes, with 882 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APOB-associated genes across cancer lineages are TUBA4A, AP1AR, and PYURF. Each is linked with APOB in more than 2 cancer types. Because this analysis shows association rather than direction, both APOB-to-partner and partner-to-APOB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBA4A grouped by APOB-low versus APOB-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APOB→partner) and Y-score (partner→APOB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TUBA4A →	-1.676	-2.000	.006	.001	3	3
LARGE_INTESTINE	AP1AR →	+0.459	+1.566	.005	<.001	3	3
LARGE_INTESTINE	PYURF →	+0.409	+1.974	<.001	<.001	3	3
LARGE_INTESTINE	ASMTL →	+0.569	+1.199	<.001	.003	3	3
SKIN	RAB3A →	+0.783	+1.290	.004	.006	3	3
SKIN	MARCKS →	-0.645	-2.048	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 882 associations by consensus.

TUBA4A by APOB expression — OVARY

Explore this box plot interactively →