APOA2

Across TCGA cell cohorts, APOA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,906 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible APOA2-associated GO terms across cancer lineages are Negative regulation of cholesterol import, Regulation of cholesterol import, and Peptidyl-methionine modification. Each is linked with APOA2 in more than 19 cancer types. Because this analysis shows association rather than direction, both APOA2-to-partner and partner-to-APOA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cholesterol import grouped by APOA2-low versus APOA2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APOA2→partner) and Y-score (partner→APOA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of cholesterol import →	+2.183	+8.477	<.001	<.001	3	20
BONE	Regulation of cholesterol import →	-0.267	-1.020	<.001	.001	3	13
LUNG_NSCLC_LUSC	Peptidyl-methionine modification →	-0.244	-1.109	.001	.005	3	9
BONE	High-density lipoprotein particle assembly →	-0.113	-0.640	<.001	.001	3	7
SOFT_TISSUE	Cytolysis in another organism →	-0.816	-0.430	.004	.004	3	5
SOFT_TISSUE	Muscle organ development →	-0.063	-0.399	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,906 associations by consensus.

Negative regulation of cholesterol import by APOA2 expression — LIVER

Explore this box plot interactively →