APOA2

Across TCGA pan-cancer cohorts, APOA2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of APOA2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where APOA2 RNA is repressed in tumor relative to normal tissue. In most cancer types APOA2 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, THCA, and STAD are the cancer types where APOA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APOA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−0.585	.003	5	view →
THCA	All	All	+0.149	<.001	5	view →
STAD	All	All	+0.961	.011	4	view →
KIRC	Male	All	−0.256	.001	4	view →
KICH	All	All	−0.212	.001	4	view →
BRCA	Female	All	+0.055	.004	4	view →
CHOL	Female	All	−8.343	<.001	3	view →
LIHC	Male	All	+0.677	.009	1	view →
COAD	All	All	+0.586	.035	1	view →
BLCA	Female	IV	+0.116	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

APOA2–KIRP

Open the KIRP breakdown →