APOA2

Across TCGA pan-cancer cohorts, APOA2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated APOA2 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher APOA2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated APOA2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

ESCA, CHOL, and UCEC are the cancer types where APOA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	All	0.392	0.633	<.001	63	view →
CHOL	OS	Quartile	II,III,IV	0.060	1.000	.004	36	view →
UCEC	DFS	Quartile	All	0.863	0.929	.015	32	view →
STAD	OS	Tertile	All	0.388	0.662	.010	29	view →
UVM	OS	Tertile	III,IV	0.424	0.729	.023	24	view →
UCS	DFS	Quartile	III,IV	0.285	0.515	.023	22	view →
DLBC	OS	Tertile	All	0.524	1.000	.009	21	view →
SKCM	OS	Tertile	IV	1.000	0.114	.001	18	view →
SCLC	OS	Tertile	IV	0.938	0.260	.049	9	view →
READ	OS	Quartile	III,IV	0.934	0.626	.039	6	view →
LUAD	DFS	Median	IV	0.275	0.721	.015	6	view →
LAML	DFS	Median	All	0.449	0.683	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

APOA2–ESCA (DFS)

Open the ESCA breakdown →