APMAP

Across TCGA patient cohorts, APMAP mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APMAP-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ERCC1. Each is linked with APMAP in more than 1 cancer types. Because this analysis shows association rather than direction, both APMAP-to-partner and partner-to-APMAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by APMAP-low versus APMAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APMAP→partner) and Y-score (partner→APMAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.155	-3.143	<.001	.018	3	1
UCEC	EGFR_pY1068 →	-0.294	-2.584	.011	.011	3	1
UCEC	ERCC1 →	-0.169	-2.584	.035	.011	3	1
UCEC	ACVRL1 →	-0.174	-2.986	.006	.035	3	1
UCEC	JNK2 →	+0.247	+2.179	.007	.034	3	1
UCEC	MEK1 →	+0.368	+2.584	.031	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by APMAP expression — UCEC

Explore this box plot interactively →