APMAP

Across TCGA pan-cancer cohorts, APMAP RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated APMAP data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher APMAP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated APMAP expression acts as an unfavorable survival marker, although some lineages such as LUAD and LIHC show a favorable association.

MESO, LUAD, and OV are the cancer types where APMAP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.270	0.495	<.001	111	view →
LUAD	OS	Tertile	II,III,IV	0.828	0.647	<.001	52	view →
OV	OS	Tertile	All	0.802	0.874	.004	50	view →
CHOL	DFS	Quartile	All	0.128	0.729	<.001	41	view →
HNSC	DFS	Quartile	II,III,IV	0.618	0.761	.002	35	view →
BLCA	DFS	Quartile	All	0.172	0.491	.007	32	view →
UCS	DFS	Median	All	0.386	0.631	.008	30	view →
SARC	OS	Median	All	0.665	0.817	.001	28	view →
LGG	OS	Tertile	All	0.709	0.907	<.001	27	view →
LIHC	OS	Median	All	0.642	0.476	.001	18	view →
CESC	DFS	Median	All	0.777	0.866	.002	16	view →
KIRP	OS	Median	III,IV	0.159	0.732	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

APMAP–MESO (OS)

Open the MESO breakdown →