APMAP

Across TCGA pan-cancer cohorts, APMAP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of APMAP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where APMAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types APMAP is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where APMAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APMAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.466	<.001	11	view →
BLCA	All	III,IV	+1.312	<.001	11	view →
STAD	Male	II,III,IV	+1.589	<.001	9	view →
KIRP	All	II,III,IV	+0.818	.001	9	view →
THCA	Male	III,IV	−0.707	<.001	9	view →
COAD	Male	II,III,IV	+0.924	<.001	8	view →
READ	All	All	+1.166	<.001	7	view →
UCEC	All	II,III,IV	+1.041	.001	6	view →
LUSC	Female	All	+0.824	<.001	6	view →
ESCA	Female	All	+1.370	<.001	4	view →
BRCA	All	III,IV	+0.526	.017	4	view →
PRAD	All	All	+0.382	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

APMAP–HNSC

Open the HNSC breakdown →